Master thesis Formulation of antimicrobials in novel drug delivery systems - Under tillsättning eller tillsatt, ej sökbar

Are you interested in finding new solutions to the increasing problem with antibiotic resistance and learn surface techniques to investigate novel drug delivery systems? Would you like to work in an innovative-driven environment with experts in formulations for pharmaceutical, foods, cosmetics, and cleaning? The Formulation development unit at RISE is seeking a highly motivated Master student with an interest in drug formulation and surfaces analysis techniques.  

Background
Antibiotic resistance of bacteria is considered one of the biggest treats to the global health according the World Health Organization (WHO). The inherent resistance development in bacteria makes antibiotics a less effective treatment over time and common infections are getting harder to treat with currently available antibiotics. On top of this, many antimicrobials are difficult to formulate into stable medications as they have problems with stability, solubility and low bioavailability. The emerging tactics to battle these issues is to invent new antimicrobial substances (e.g., biologics) and/or reformulate of already existing antibiotics. One possibility would be to use innovative micro- or nanocarriers as a drug delivery system for antimicrobial substances

Goal
The goal of the project is to investigate and evaluate different micro- or nanocarriers as drug delivery systems for antimicrobials, and study their interactions with model membranes that mimic either bacteria or human cells. The work will entail: a short literature study, laboratory work divided into formulation and characterization of drug carriers (DLS, Zeta-potential, drug solubility, drug release) and surface analysis techniques for interaction studies between carriers and model membranes (QCM-D, Ellipsometry, SAXS).

Who are you?
For this diploma work, the student should be enrolled in a master project in pharmacy, biotechnology/chemical engineering or similar and have a background knowledge on drug formulation. 

Terms
Project period: Spring term 2022, 30 hp. Start upon agreement.
Placement: RISE, Malvinas väg 3, Stockholm.

Welcome with your application!
For questions and more information, please contact Lina Nyström, 010-516 65 33. Last day for application is 31 December 2021. Interviews with candidates will be conducted continuously and decision of acceptance can be made at any point.

Master thesis, Formulation, Surface analysis techniques, Antibiotics, RISE, Stockholm